Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias

Figure 6 Comparative analysis of connexin-43 expression via immunohistochemistry across the experimental groups. A: Immunohistochemical staining results of connexin-43 (Cx43) channel protein in ventricular myocardial tissues of rats; B: Quantitative analysis of Cx43 expression levels in ventricular myocardial tissues; C: Immunohistochemical staining results of sodium 1.5 ion (Nav1.5) channel protein in ventricular myocardial tissues of rats; D: Quantitative analysis of Nav1.5 channel expression levels in ventricular myocardial tissues; E and F: Protein expression levels of Cx43/Nav1.5 channel in rat ventricular myocardial tissue were detected by western blot, with glyceraldehyde-3-phosphate dehydrogenase as the internal control. Quantitative analysis of the above protein expressions was conducted. ^aP < 0.05 vs control, ^bP < 0.05 vs sepsis group, ^cP < 0.01 vs control, ^dP < 0.001 vs control, ^eP < 0.001 vs sepsis group and n = 3. Original magnification was 20 ×, n = 3. All data are expressed as mean ± SD. Cx43: Connexin-43; Nav1.5: Sodium 1.5 ion; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.