Gut microbiota-derived metabolite trimethylamine N-oxide in major adverse cardiovascular events: Mechanisms, risk assessment, and therapeutic strategies

doi:10.4330/wjc.v18.i3.116780

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World Journal of Cardiology

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1949-8462

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Mar 26, 2026; 18(3): 116780
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.116780

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Figure 3 Components of major cardiovascular events. Elevated trimethylamine N-oxide levels contribute to the development of various cardiovascular diseases that are classified as major cardiovascular events. These factors derived from mechanisms such as inflammation, myocardial fibrosis, atherosclerosis, neuroinflammation, platelet activation, atherosclerotic plaque rupture and instability, and thrombus formation. TMAO: Trimethylamine N-oxide.

Citation: Jaimez Alvarado S, Flores Enciso MF, Amedei A, Aguirre García MM. Gut microbiota-derived metabolite trimethylamine N-oxide in major adverse cardiovascular events: Mechanisms, risk assessment, and therapeutic strategies. World J Cardiol 2026; 18(3): 116780
URL: https://www.wjgnet.com/1949-8462/full/v18/i3/116780.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i3.116780

Jaimez Alvarado S, Flores Enciso MF, Amedei A, Aguirre García MM. Gut microbiota-derived metabolite trimethylamine N-oxide in major adverse cardiovascular events: Mechanisms, risk assessment, and therapeutic strategies. World J Cardiol 2026; 18(3): 116780 [DOI: 10.4330/wjc.v18.i3.116780]

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