Semaglutide in patients with obesity and heart failure with preserved ejection fraction: A systematic review and meta-analysis

doi:10.4330/wjc.v18.i3.112189

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World Journal of Cardiology

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1949-8462

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Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Cardiol. Mar 26, 2026; 18(3): 112189
Published online Mar 26, 2026. doi: 10.4330/wjc.v18.i3.112189

Table 1 Key characteristics of the included studies

Ref.	Study design	Population characteristics	Type of HF	Intervention	Control
Kosiborod et al[44], 2024	RCT (STEP-HFpEF DM)	O with HF and DM-II	HFpEF	Semaglutide (2.4 mg)	Placebo
Butler et al[45], 2023	RCT (STEP-HFpEF)	O with HF	HFpEF	Semaglutide (2.4 mg)	Placebo
Rehman et al[46], 2024	Retrospective	O with HF	HFpEF	Semaglutide (2.4 mg)	Placebo

O: Obesity; HF: Heart failure; RCT: Randomized control trial; DM-II: Type 2 diabetes; HFpEF: Heart failure with preserved ejection fraction.

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Citation: Mylavarapu M, Obi O, Abarca Y, Fatima H, Roshni P, Huda NU, Lysak Y, Gandapur A, Vazquez SC, Siddiqui MA, Mowo-Wale A. Semaglutide in patients with obesity and heart failure with preserved ejection fraction: A systematic review and meta-analysis. World J Cardiol 2026; 18(3): 112189
URL: https://www.wjgnet.com/1949-8462/full/v18/i3/112189.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i3.112189

Mylavarapu M, Obi O, Abarca Y, Fatima H, Roshni P, Huda NU, Lysak Y, Gandapur A, Vazquez SC, Siddiqui MA, Mowo-Wale A. Semaglutide in patients with obesity and heart failure with preserved ejection fraction: A systematic review and meta-analysis. World J Cardiol 2026; 18(3): 112189 [DOI: 10.4330/wjc.v18.i3.112189]

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