Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine

doi:10.4330/wjc.v18.i2.111032

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Feb 26, 2026; 18(2): 111032
Published online Feb 26, 2026. doi: 10.4330/wjc.v18.i2.111032

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Figure 3 Catecholaminergic polymorphic ventricular tachycardia treatment algorithm. Systematic treatment algorithm for catecholaminergic polymorphic ventricular tachycardia management incorporating risk stratification, first-line β-blocker therapy, adjunctive pharmacological interventions, and advanced therapeutic options, including left cardiac sympathetic denervation and implantable cardioverter defibrillator implantation for refractory cases. CPVT: Catecholaminergic polymorphic ventricular tachycardia; ECG: Electrocardiogram; RyR2: Ryanodine receptor 2; CASQ2: Calcium-sensing machinery, such as calsequestrin; CALM1-3: Calmodulin 1-3; TRDN: Triadin; LSCD: Left cardiac sympathetic denervation; ICD: Implantable cardioverter defibrillator; QoL: Quality of life.

Citation: Sharma V. Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine. World J Cardiol 2026; 18(2): 111032
URL: https://www.wjgnet.com/1949-8462/full/v18/i2/111032.htm
DOI: https://dx.doi.org/10.4330/wjc.v18.i2.111032

Sharma V. Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine. World J Cardiol 2026; 18(2): 111032 [PMID: 41694040 DOI: 10.4330/wjc.v18.i2.111032]

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