Correlation of APOE, SLCO1B1 and LPA KIV-2 gene polymorphisms with coronary heart disease in the Teochew population

Table 6 Logistic regression analysis of coronary heart disease risk in Teochew populations

Variables	Unadjusted values		Adjusted values
	OR (95%CI)	P value	OR (95%CI)	P value
Male	2.343 (1.552-3.537)	< 0.001	2.559 (1.395-4.692)	0.002
Age, years	1.050 (1.032-1.067)	< 0.001	1.063 (1.040-1.085)	< 0.001
Hypertension	3.174 (2.086-4.831)	< 0.001	2.358 (1.420-3.917)	0.001
Diabetes	4.034 (2.251-7.230)	< 0.001	3.609 (1.813-7.184)	< 0.001
History of smoking	2.332 (1.448-3.757)	< 0.001	2.042 (1.092-3.818)	0.025
TG, mmol/L	1.581 (1.009-2.447)	0.046	1.526 (0.855-2.725)	0.153
HCY, μmol/L	3.282 (1.824-5.906)	< 0.001	1.888 (0.933-3.819)	0.077
HDL-C, mmol/L	0.363 (0.227-0.581)	< 0.001	0.577 (0.308-1.083)	0.087
ApoA1, g/L	2.320 (1.517-3.548)	< 0.001	1.402 (0.793-2.478)	0.245
LP(a), mg/L	2.358 (1.371-4.056)	0.002	1.577 (0.742-3.350)	0.236
Genotype
E2	0.507 (0.302-0.850)	0.010	0.395 (0.209-0.745)	0.004
E4	1.218 (0.669-2.219)	0.519	1.028 (0.500-2.110)	0.941
SLCO1B1	1.355 (0.824-2.229)	0.231	1.666 (0.896-3.096)	0.107
KIV	0.954 (0.933-0.976)	< 0.001	0.949 (0.919-0.979)	0.001

E2 (ε2/ε2, ε2/ε3), reference genotype: Ε3/ε3; E4 (ε4/ε4, ε3/ε4), reference genotype: Ε3/ε3; SLCO1B1(*1a/*5 plus *1a/*15 plus *1b/*15 plus*15/*15), reference genotype: *1a/*1a plus *1a/*1b plus*1b/*1b. TG: Triglycerides; HCY: Homocysteine; HDL-C: High-density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; Lp(a): Lipoprotein(a).