Effect of extracorporeal membrane oxygenation combined with hemoperfusion on inflammatory factors in patients with cardiogenic shock

Table 2 Inflammatory factors and clinical indicator in two groups

	T0	T6	T12	D1	D2	D3	P value
C-reactive protein, mg/L
ECMO	36.0 (10.4, 107.7)	62.7 (37.4, 124.9)	74.5 (48.7, 123.1)	98.5 (59.0, 152.6)	132.8 (75.2, 181.4)	130.8 (84.9, 193.3)	< 0.001
ECMO+HP	34.6 (22.4, 113.3)	128.3 (63.6, 178.3)a	65.3 (37.3, 91.0)a	43.2 (25.9, 64.6)a	31.5 (21.2, 53.9)a	18.3 (9.7, 25.6)a	< 0.001
Interleukin-6, pg/mL
ECMO	203.5 (118.7, 420.0)	310.6 (221.0, 462.9)	341.0 (133.9, 549.5)	247.3 (175.2, 460.6)	391.9 (234.8, 494.2)	339.9 (202.0, 485.4)	0.109
ECMO+HP	214.1 (160.9, 388.0)	146.3 (108.9, 225.4)a	101.0 (69.2, 123.4)a	57.0 (45.4, 78.5)a	32.7 (24.3, 47.5)a	11.9 (9.3, 15.6)a	< 0.001
Lactic acid, mmol/L
ECMO	14.6 (11.0, 17.4)	17.9 (14.0, 20.7)	17.4 (14.2, 21.0)	17.9 (13.2, 20.4)	18.0 (14.4, 20.6)	16.2 (12.7, 20.7)	0.115
ECMO+HP	16.1 (12.7, 18.4)	5.5 (2.7, 11.4)a,b	2.9 (1.9, 4.5)a,b	1.8 (1.5, 2.4)a,b	1.4 (1.2, 2.0)a,b	1.3 (0.9, 2.5)a,b	< 0.001
Tumor necrosis factor-α, pg/mL
ECMO	416.6 ± 81.8	423.0 ± 68.4	420.6 ± 75.4	414.1 ± 70.0	435.5 ± 70.0	420.1 ± 69.4	0.834
ECMO+HP	412.0 ± 90.7	307.1 ± 95.1a	249.6 ± 84.1a,b	216.0 ± 79.0a,b	178.2 ± 66.4a,b	123.3 ± 58.5a,b	< 0.001
Mean arterial pressure, mmHg
ECMO	60.2 ± 9.4	61.3 ± 7.5	61.5 ± 6.3	63.2 ± 6.6	64.8 ± 8.0	62.4 ± 6.8	0.312
ECMO+HP	58.9 ± 8.5	59.5 ± 7.4	60.0 ± 5.4	61.3 ± 6.9	62.0 ± 6.0	60.8 ± 6.4	0.187

^aP < 0.05 vs ECMO group (two-way analysis of variance with Fisher’s least significant difference post hoc).

^bP < 0.05 vs T0 within group (Wilcoxon signed-rank test).

ECMO: Extracorporeal membrane oxygenation; HP: Hemoperfusion.