RAF1 mutation expands the cardiac phenotypic spectrum of Noonan syndrome: A case report

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Jun 26, 2025 (publication date) through Jun 26, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Jun 26, 2025; 17(6): 106525
Published online Jun 26, 2025. doi: 10.4330/wjc.v17.i6.106525

Table 2 Follow-up data on the child’s left ventricular outflow tract, tricuspid valve flow velocity, and pressure

Date	Left ventricular outflow tract (resting state)	Vmax (m/second)	PGmax (mmHg)	Tricuspid regurgitation Vmax (m/second)	Tricuspid regurgitation PGmax (mmHg)	Pulmonary artery systolic pressure (mmHg)
July 11, 2024	Significantly increased	4.7	89	3.2	40	-
July 30, 2024	Increased	3.8	57	2.6	27	32
August 31, 2024	Increased	3.4	47	2.0	17	22
September 11, 2024	Increased	3.4	45	2.0	17	22
February 12, 2025	Normal	1.8	13	2.2	20	25

PGmax: Peak gradient maximum; Vmax: Velocity maximum.

Citation: Ma N, Li ZW, Liu JJ, Liu XG, Zhou X, Wang BW, Li YL, Zhang TC, Xie P. RAF1 mutation expands the cardiac phenotypic spectrum of Noonan syndrome: A case report. World J Cardiol 2025; 17(6): 106525
URL: https://www.wjgnet.com/1949-8462/full/v17/i6/106525.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i6.106525