Comparison of beta-blockers vs calcium channel blockers in heart failure with preserved ejection fraction

doi:10.4330/wjc.v17.i12.115254

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Dec 26, 2025; 17(12): 115254
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.115254

Table 4 Comparative safety outcomes of beta-blockers vs calcium channel blockers

Outcome	BB (%)	CCB (%)	P value
Symptomatic bradycardia	9.2	4.9	0.000
Hypotension	7.2	11.5	0.000
Syncope	4.6	3.5	0.110
Worsening renal function	6.8	8.0	0.147
Drug discontinuation	11.3	9.3	0.043
Hospitalization due to ADR	5.1	5.6	0.623

This table displays the incidence of predefined safety endpoints in the beta-blocker and calcium channel blocker groups, expressed as the percentage (%) of patients experiencing the event. Safety outcomes were evaluated as proportions, with statistical comparisons conducted using χ² tests. BB: Beta-blockers; CCB: Calcium channel blockers; ADR: Adverse reaction.

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Citation: Mansoor M, Depar FN, Talha HU, Rashid HU, Ashraf A, Nouman M, Abbas M, Abbasi MT, Sher A. Comparison of beta-blockers vs calcium channel blockers in heart failure with preserved ejection fraction. World J Cardiol 2025; 17(12): 115254
URL: https://www.wjgnet.com/1949-8462/full/v17/i12/115254.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i12.115254

Mansoor M, Depar FN, Talha HU, Rashid HU, Ashraf A, Nouman M, Abbas M, Abbasi MT, Sher A. Comparison of beta-blockers vs calcium channel blockers in heart failure with preserved ejection fraction. World J Cardiol 2025; 17(12): 115254 [PMID: 41479995 DOI: 10.4330/wjc.v17.i12.115254]

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