Predictors of life-threatening events in adult patients with left ventricular noncompaction

Figure 2 Predicting adverse outcomes in left ventricular noncompaction: From individual predictors to integrated risk models. A-C: Main predictors of fatal outcomes in patients with left ventricular noncompaction. The receiver operating characteristic curve indicated that New York Heart Association (NYHA) chronic heart failure class [area under the curve (AUC) = 0.731, P = 0.002], left ventricular ejection fraction (AUC = 0.767, P < 0.001), and the E/A ratio (AUC = 0.786, P = 0.001) were predictors of fatal outcome in patients with left ventricular noncompaction; D: Receiver operating characteristic curve of the mathematical model of the predictive value to determine the risk of fatal outcomes in patients with left ventricular noncompaction. The model included the following variables: E/A ratio > 1.9; left ventricular ejection fraction < 35%; left ventricular outflow tract velocity-time integral < 11; and NYHA chronic heart failure class ≥ 3; E: Receiver operating characteristic curve of the model of the predictive value of ventricular tachycardia development in patients with left ventricular noncompaction. The model included the following variables: NYHA chronic heart failure class ≥ 3; left ventricular end diastolic diameter > 6.1 cm; left ventricular ejection fraction < 40%; QRS duration > 105 ms; systolic pulmonary artery pressure > 32 mmHg; presence of myocarditis; poor R-wave progression in the chest leads; and low QRS voltage. NYHA: New York Heart Association; LVEF: Left ventricular ejection fraction; VT: Ventricular tachycardia.