Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban

doi:10.4330/wjc.v17.i12.112046

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Dec 26, 2025; 17(12): 112046
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.112046

Table 6 Apixaban levels and clotting time-pre and clotting time-post drug administration in the four drug dose regimens as described in methods, mean (minimum-maximum)

Parameter	1	2	3	4	P value
Apx-trough	12 (11-13}	34 (6-89)	131 (40-285)	176 (93-269)	0.020
Apx-peak	71 (55-87)	125 (68-202)	194 (90-330)	248 (220-274)	0.048
CT-pre¹	72 (67-77)	70 (65-76)	92 (71-139)	92 (86-103)	0.099
CT-post²	118 (116-120)	84 (74-104)	103 (75-156)	106 (102-113)	0.323

¹Prior administration of apixaban.

²After administration of apixaban.

Apx-trough and Apx-peak, apixaban peak and trough levels respectively. Apx: Apixaban; CT: Clotting time.

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Citation: Bacharaki D, Kyriakou E, Sardeli A, Nikolopoulos P, Triantaphyllis G, Drakou A, Makris F, Spanou E, Triantou E, Haviaras E, Fatourou A, Poulis A, Tsantes A, Kyriazis J, Lionaki S. Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban. World J Cardiol 2025; 17(12): 112046
URL: https://www.wjgnet.com/1949-8462/full/v17/i12/112046.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i12.112046

Bacharaki D, Kyriakou E, Sardeli A, Nikolopoulos P, Triantaphyllis G, Drakou A, Makris F, Spanou E, Triantou E, Haviaras E, Fatourou A, Poulis A, Tsantes A, Kyriazis J, Lionaki S. Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban. World J Cardiol 2025; 17(12): 112046 [PMID: 41479990 DOI: 10.4330/wjc.v17.i12.112046]

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