Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban

doi:10.4330/wjc.v17.i12.112046

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Dec 26, 2025; 17(12): 112046
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.112046

Table 3 Correlations of EXTEM clotting time with apixaban levels and Platelet Function Analyzer-200 assay

	Apx-trough	Apx-peak	Apxdiff	CT-pre	CT-post	CTdiff	PFA-200
Apx-trough	1	0.882^b		770^c
Apx-peak	0.882^c	1		0.767^c	0.526^a
Apxdiff			1			0.464^a
CT-pre¹	0.770^c	0.767^c		1	0.616^b
CT-post²		0.526^a		0.616^b	1	0.645^b
CT-diff			0.464^a		0.645^b	1	0.565^a
PFA-200						0.565^a	1

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

¹Prior administration of apixaban.

²After administration of apixaban.

Apx: Apixaban; Apxdiff: Difference between peak and trough levels of apixaban; CT: Clotting time; CTdiff: Difference between EXTEM clotting time after and prior administration of apixaban; PFA-200: Platelet Function Analyzer-200.

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Citation: Bacharaki D, Kyriakou E, Sardeli A, Nikolopoulos P, Triantaphyllis G, Drakou A, Makris F, Spanou E, Triantou E, Haviaras E, Fatourou A, Poulis A, Tsantes A, Kyriazis J, Lionaki S. Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban. World J Cardiol 2025; 17(12): 112046
URL: https://www.wjgnet.com/1949-8462/full/v17/i12/112046.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i12.112046

Bacharaki D, Kyriakou E, Sardeli A, Nikolopoulos P, Triantaphyllis G, Drakou A, Makris F, Spanou E, Triantou E, Haviaras E, Fatourou A, Poulis A, Tsantes A, Kyriazis J, Lionaki S. Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban. World J Cardiol 2025; 17(12): 112046 [PMID: 41479990 DOI: 10.4330/wjc.v17.i12.112046]

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