Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction

Table 5 Diagnostic value of microRNA polymorphisms in acute myocardial infarction

Ref.	Patients, n	miRNA	Analyzed model	Standard	OR (95%CI)	P value
Wang et al[55], 2017	353 CAD	microRNA-146a, rs2431697	T allele carriers	MALDI-TOF MS, Sequenom MassARRAY system	1.26 (1.04-1.53)	0.018
		microRNA-146a, rs2910164	G allele carriers		0.73 (0.62-0.86)	< 0.001
Tie et al[56], 2023	151 CAD	microRNA-146a, rs2910164	Dominant (CG + GG vs CC)	Real-time PCR	1.59 (0.76–2.81)	0.014
			Recessive (CC vs TT + TC)		0.91 (0.53–2.04)	0.320
		miRNA-146a, rs41291957	Dominant (AA + GA vs GG)		0.71 (0.53–1.35)	0.680
			Recessive (AA vs GG + GA)		0.66 (0.21–1.12)	0.17
Agiannitopoulos et al[58], 2020	80 MI	miRNA-146a, rs2910164	Dominant (CC + CG vs GG)	PCR-RFLP, HRM, Sanger Sequencing	0.97 (0.57-1.63)	1.000
			Recessive (CG + GG vs CC)		1.37 (0.55-3.37)	0.478
		miRNA-149a, rs2292832	Dominant (CT + TT vs CC)		1.03 (0.61-1.74)	1.000
			Recessive (CC + CT vs TT)		1.18 (0.56-2.47)	0.700
		miRNA-196aC, rs11614913	Dominant (CT + TT vs CC)		1.73 (1.02-2.92)	0.047
			Recessive (CC + CT vs TT)		2.44 (1.13-5.27)	0.031
		miRNA-499, rs3746444	Dominant (AG + GG vs AA)		1.87 (1.08-3.24)	0.031
			Recessive (AA + AG vs GG)		2.05 (1.07-3.90)	0.035
Huang et al[42], 2015	718 ACS	miRNA-146a, rs11614913	Dominant (TC + CC vs TT)	Real time quantitative PCR system	1.10 (0.84-1.44)	0.488
			Recessive (CC vs TT + TC)		1.00	-
	717 ACS	miRNA-146a, rs2910164	Dominant (CG + GG vs CC)		0.77 (0.60-0.99)	0.044
			Recessive (CC + CG vs GG)		1.07 (0.79-1.45)	0.673
Zhao et al[59], 2019	5202 CHD	miRNA-146a, rs2910164	Dominant (CC vs CG + GG)	Systematic review	0.8 (0.73–0.87)	< 0.001
			Recessive (CC + CG vs GG)		0.86 (0.76-0.98)	< 0.001

CAD: Coronary artery disease; CHD: Congenital heart disease; CI: Confidence interval; HRM: High-resolution melting analysis; MALDI-TOF MS: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; MI: Myocardial infarction; OR: Odds ratio; RFLP: Restriction fragment length polymerase.