Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction

Table 1 Diagnostic value of circulating microRNA levels in acute myocardial infarction

Ref.	Patients (n)	miRNA			Standard	AUC	95%CI	P value
Zhang et al[28], 2015	110 AMI	miRNA-486			Quantitative real-time PCR	0.731	-	< 0.001
		miRNA-150				0.678	-	< 0.001
		miRNA-486 miRNA-150				0.771	-	< 0.001
Peng et al[29], 2014	186 AMI	miRNA -133			Quantitative reverse transcriptase-PCR	0.912	-	< 0.001
		miRNA-1291				0.695		< 0.001
		miRNA-663b				0.611		< 0.01
Wang et al[30], 2014	45 AMI	miRNA-361-5p		0 hours	Quantitative real-time PCR	0.881	0.777–0.985	< 0.001
				4 hours		0.883	0.777–0.989	< 0.001
				24 hours		0.838	0.716–0.961	< 0.001
		miRNA-21-5p		0 hour		0.949	0.872–1.000	< 0.001
				4 hours		0.947	0.000–1.000	< 0.001
				24 hours		0.791	0.655–0.927	0.001
		miRNA-519e-5p		0 hours		0.798	0.663–0.934	0.001
				4 hours		0.801	0.668–0.934	0.002
				24 hours		0.908	0.818–0.997	< 0.001
		Combined score		0 hour		0.989	0.000–1.000	< 0.001
				4 hours		1.000	0.000–1.000	< 0.001
				24 hours		0.995	0.000–1.000	< 0.001
Zhao et al[31], 2023	183 ACS	miRNA-483-5p			Quantitative reverse transcriptase-PCR	0.919	0.881-0.957	-
	78 AMI					0.867	0.800-0.933	-
Xue et al[32], 2019	31 AMI	miRNA-26a-1	Pre-PCI		Quantitative real-time PCR	0.965	-	< 0.001
			Post-PCI			0.939	-	< 0.001
		miRNA-146a	Pre-PCI			0.911	-	< 0.001
			Post-PCI			0.932	-	< 0.001
		miRNA-199a-1	Pre-PCI			0.855	-	< 0.001
			Post-PCI			0.823	-	< 0.001
		Combined	Pre-PCI			0.913	-	< 0.001
			Post-PCI			0.890	-	< 0.001

ACS: Acute coronary syndrome; AMI: Acute myocardial infarction; AUC: Area under the curve; CI: Confidence interval; PCI: Percutaneous coronary intervention.