Continuous positive airway pressure therapy for patients with obstructive sleep apnea and coronary artery disease

Figure 5 Integrated therapeutic strategies for managing patients with comorbid obstructive sleep apnea and coronary artery disease. Effective treatment of obstructive sleep apnea (OSA)–coronary artery disease overlap requires a dual-pronged approach targeting both conditions. Management of OSA includes consistent use of continuous positive airway pressure (CPAP) therapy for ≥ 4 hours per night, with mandibular advancement devices or upper airway surgery considered in cases of CPAP intolerance. Cardiovascular risk factors should be concurrently addressed through antiplatelet therapy, blood pressure control, lipid and glucose management, and avoidance of non-selective beta-blockers. Lifestyle interventions—including diet, weight control, and physical activity—are essential to optimize long-term outcomes. Multidisciplinary collaboration further reinforces the effectiveness and sustainability of integrated care. CAD: Coronary artery disease; CPAP: Continuous positive airway pressure; OSA: Obstructive sleep apnea; MAD: Mandibular advancement devices.