Cardiometabolic risk factors in young Indian men and their association with parameters of insulin resistance and beta-cell function

Table 3 Comparison of cardiometabolic and glycaemic variables for men depending upon different categories of beta-cell function (oral disposition index)

Variable	Quartile 4 oDI > 75th percentile of total cohort n = 158	Quartile 2-3 oDI 25th to 75th percentile of total cohort n = 319	Quartile 1 oDI < 25th percentile of total cohort n = 158	P valuea
Age (yr)	33.1 ± 5.1	33.8 ± 4.9	35.0 ± 5.3	0.003
Family H/O diabetes	48 (30.4)	124 (38.9)	73 (46.2)	0.015
BMI (kg/m2)	25.0 ± 3.9	25.9 ± 3.8	27.2 ± 3.7	< 0.001
BMI ≥ 25 kg/m2	75 (47.5)	195 (61.1)	118 (74.7)	< 0.001
Waist circumference (cm)	91.8 ± 9.5	93.6 ± 9.5	97.6 ± 9.1	< 0.001
Waist circumference ≥ 90 cm	93 (58.9)	224 (70.2)	131 (84.0)	< 0.001
Systolic BP ≥ 140 mmHg	9 (5.7)	20 (6.3)	17 (10.8)	0.135
Diastolic BP ≥ 90 mmHg	15 (9.5)	53 (16.6)	43 (27.4)	< 0.001
Hypertension	19 (12.0)	56 (17.6)	48 (30.6)	< 0.001
Total cholesterol ≥ 5.2 mmol/L	32 (20.3)	106 (33.3)	55 (34.8)	0.005
LDL-C ≥ 2.6 mmol/L	79 (50.0)	196 (61.6)	103 (65.2)	0.013
HDL-C < 1.03 mmol/L	80 (50.6)	163 (51.3)	93 (58.9)	0.232
Triacylglycerol ≥ 1.7 mmol/L	51 (32.3)	139 (43.7)	91 (57.6)	< 0.001
The metabolic syndrome	42 (26.6)	118 (37.0)	98 (62.0)	< 0.001
HOMA-IR (mmol/L × µIU/mL)	2.1 (1.2-3.0)	2.6 (1.9-3.7)	4.0 (2.7-6.0)	< 0.001
Insulinogenic index (pmolins/mmolglu)	410.5 (257.1-651.6)	215.6 (146.6-299.4)	85.6 (51.2-127.7)	< 0.001
Disposition index (l/mmolglu)	6.1 (4.9-9.1)	2.6 (2.0-3.3)	0.8 (0.5-1.2)	< 0.001
Dysglycaemia	57 (36.1)	147 (46.1)	127 (80.4)	< 0.001

^aData are the mean ± SD, median (q25-q75), or n (%). H/O: History of; BMI: Body mass index; BP: Blood pressure; LDL-C: Low density lipoprotein-cholesterol; HDL-C: High density lipoprotein-cholesterol; HOMA-IR: Homeostatic model assessment for insulin resistance.