Sodium glucose cotransporter 2 inhibitors: New horizon of the heart failure pharmacotherapy

Table 2 Summary of clinical trials of sotagliflozin

Ref.	Population (n)	Age, yr (median)	Follow-up period (median)	Patients with a history of HF	Patients with a history of CAD	Main results
SCORED[7]	T2DM and CKD (10584)	63	16 mo	31.0%	22.4%	CV death or HF (HR, 0.74; 95%CI, 0.63–0.88)
						CV death (HR, 0.90; 95%CI, 0.73–1.12)
SOLOIST-WHF[8]	T2DM and HF (1222)	70	9.2 mo	100%	58.3%	CV death or HF (HR, 0.67; 95%CI, 0.52–0.85)
						CV death (HR, 0.84; 95%CI, 0.58–1.22)

HF: Heart failure; CAD: Coronary artery disease (numbers indicate % of patients with coronary revascularization in the SCORED trial and % of those with ischemic heart disease in the SOLOIST-WHF trial); T2DM: Type 2 diabetes mellitus; CKD: Chronic kidney disease; CV: Cardiovascular; HF: Heart failure; HR: Hazard ratio; CI: Confidence interval.