Percutaneous devices for left atrial appendage occlusion: A contemporary review

Table 1 Comparison of left atrial appendage occlusion devices

Device	Study	Year of Introduction	Description	Approach	Approval
Atriclip Device System (Atricure)	EXCLUDE study[33]	2008	Self-closing, sterile, implantable clip, with a reusable deployment tool applied pericardially.	Epicardial	CE Mark
Tiger Paw System (Terumo Cardiovascular Systems)	Slater et al[34]	Introduced in 2009 and recalled in 2015	Implantable fastener of titanium connectors that staples the LAA tissue plus rims of silicone that seal the puncture sites.	Epicardial	Recalled
Lariat device (SentreHEART)	Bartus et al[36]; Massumi et al[37]; Dar et al[38]	2009	Multicomponent system including: transvenous and epicardial balloon catheters, magnet tipped guidewires, and suture delivery system	Epicardial and transvenous	FDA approval for soft tissue closure not LAAO CE mark
PLAATO (Appriva Medical)	Sievert et al[43]; Ostermaye et al[44]; Bayard et al[45]; Park et al[46]	Introduced in 2001and discontinued in 2007	Self-expanding nitinol cage covered with polymeric membrane (ePTFE) designed to be placed in the orifice of the LAA	Transvenous, trans-septal	Discontinued
Watchman (Boston Scientific)	Pilot study[47]; PROTECT AF study[48-50]; PREVAIL study[51,52]; CAP 1 registry[53]; CAP 2 registry[54]; EWOLUTION registry[55-57]; RELEXAO Registry[72]; ASAP study[58]; ASAP TOO study[59]	2005	Self-expanding nitinol frame structure with fixation barbs and a permeable polyester fabric that covers the atrial facing surface of the device	Transvenous, trans-septal	FDA approved and CE Mark
ACP (St. Jude Medical)	Urena et al[67]; Gloekler et al[60]; Abualsaud et al[61]; Korsholm et al[64]; Berti et al[65]; RELEXAO; Registry[72]	2008	Self-expanding distal lobe (6.5mm in length) and proximal disc (4-6mm larger than distal lobe) nitinol mesh with articulating waist	Transvenous, trans-septal	CE Mark
Amplatzer Amulet (St. Jude Medical)	Gloekler et al[60]; Abualsaud et al[61]; Landmesser et al[62]; Tzikas et al[63]; Korsholm et al[64]; Berti et al[65]; Kleinecke et al[66]; RELEXAO; Registry[72];	2013	Self-expanding distal lobe and proximal disc nitinol mesh with articulating waist, and more anchors	Transvenous, trans-septal	CE Mark

LAAO: Left atrial appendage occlusion; FDA: Food and drug administration; ACP: Amplatzer cardiac plug.