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Publication Name
World Journal of Cardiology
ISSN
1949-8462
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2019.
World J Cardiol. Oct 26, 2019; 11(10): 221-235
Published online Oct 26, 2019. doi: 10.4330/wjc.v11.i10.221
Table 3 Advantages and disadvantages of different cell types for modeling disease in vitro
PropertiesFibroblastsiPSCs
Proliferation capacity+++
Self-renewalNoYes
LongevityLimitedUnlimited
DifferentiationNoYes
MetabolismQuiescentEnergetic
AcquisitionEasyDifficult
Cost++++
Ease of maintenanceSimpleDifficult
Necessary expertiseLowHigh
Disease modeling+++
StructureSingle elongated cellsRound colonies/beating CM sheets
MaturationNot applicableRequired for CM
iPSCs: Induced pluripotent stem cells; CM: Cardiomyopathy.
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