NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

doi:10.4330/wjc.v10.i9.97

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Sep 26, 2018; 10(9): 97-109
Published online Sep 26, 2018. doi: 10.4330/wjc.v10.i9.97

Table 3 Differential expression of apoptosis genes in NBCe1-null hearts

Gene symbol	Description	Fold change	P value
Xkr8	X Kell Blood Group Precursor Related 8	0.61	0.015
Rac3	RAS-Related C3 Botulinum Substrate 3	0.36	0.016
Thbs1	Thrombospondin 1	0.79	0.020
Zfp13	Zinc Finger Protein 13	0.46	0.023
Sh3glb1	SH3-Domain GRB2-like B1 (Endophilin)	1.13	0.024
Siva1	SIVA1, Apoptosis-Inducing Factor	0.66	0.030
Msrb3	Methionine Sulfoxide Reductase B3	1.19	0.002
Xlrl	Xlr-like	1.77	0.003
Ier5	Immediate Early Response 5	0.80	0.005
Hint1	Histidine Triad Nucleotide Binding Protein 1	0.84	0.010
Stmn1	Stathmin 1	1.37	0.010

Differential mRNA expression is presented as fold-changes in NBCe1-null hearts (Slc4a4^flx/flx^(Cre)) relative to WT (Slc4a4^flx/flx) hearts. The first six genes on this list were identified based on inclusion in the two apoptosis GO categories identified in Table 1.

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Citation: Vairamani K, Prasad V, Wang Y, Huang W, Chen Y, Medvedovic M, Lorenz JN, Shull GE. NBCe1 Na⁺-HCO3^- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo. World J Cardiol 2018; 10(9): 97-109
URL: https://www.wjgnet.com/1949-8462/full/v10/i9/97.htm
DOI: https://dx.doi.org/10.4330/wjc.v10.i9.97

Vairamani K, Prasad V, Wang Y, Huang W, Chen Y, Medvedovic M, Lorenz JN, Shull GE. NBCe1 Na⁺-HCO3^- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo. World J Cardiol 2018; 10(9): 97-109 [PMID: 30344957 DOI: 10.4330/wjc.v10.i9.97]

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