NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

Table 2 Ion channel and transporter genes altered in NBCe1-null hearts

Gene symbol	Description	Fold change	P value
Kcnj2	Inwardly-rectifying K+ channel J2	1.18	0.02
Kcnj11	Inwardly-rectifying K+ channel J11	1.14	0.03
Kcnk2	K+ channel K2; TREK-1	1.65	0
Kcna4	K+ channel, shaker-related 4; Kv1.4	1.50	0.05
Cacna1s	L type Ca2+ channel, alpha 1S subunit	1.44	0
Cacnb1	Ca2+ channel, beta 1 subunit	0.51	0
Atp2a1	Skeletal muscle SR Ca2+ pump	1.82	0.04
Slc9a1	Sarcolemmal Na+/H+ Exchanger	1.18	0.05
Slc9a9	Organellar Na+/H+ Exchanger	1.44	0.03
Slc16a3	Monocarboxylic acid transporter,	1.92	0.04
Slc1a5	Neutral amino acid transporter	0.81	0.04
Slc7a1	Cationic amino acid transporter, y+ system	1.24	0
Slc15a2	Proton/peptide transporter	1.87	0.01
Slc15a1	Oligopeptide transporter	0.56	0.03
Slc40a1	Iron transporter; ferroportin	0.86	0.02
Slc39a13	Zinc transporter	1.23	0.03
Slc36a1	Proton/amino acid symporter	0.83	0.05

Differential mRNA expression is presented as fold-changes in NBCe1-null hearts (Slc4a4^flx/flx(Cre)) relative to WT (Slc4a4^flx/flx) hearts.