Cardiac implications of thrombotic thrombocytopenic purpura

Figure 1 Recommendations on clinical assessment and management of cardiac involvement of thrombotic thrombocytopenia purpura. All patients with a diagnosis of thrombotic thrombocytopenia purpura (TTP) should be given low dose aspirin daily and screened for cardiac involvement by clinical cardiac symptoms, cardiac biomarkers (cardiac troponin, B-type natriuretic peptide etc) and electrocardiogram. Positive screen of cardiac involvement of TTP predicts adverse outcome, requiring further evaluation and treatment as recommended above. TTP: Thrombotic thrombocytopenia purpura; cTn, Cardiac troponin; BNP: B-type natriuretic peptide; ECG: Electrocardiogram; ACEi: Angiotensin converting enzyme inhibitors; ARB: Angiotensin receptor blockers; LVAD: Left ventricular assist device; ECMO: Extracorporeal membrane oxygenation.