Coronary heart disease: Significance of liver X receptor α genomics

Figure 1 Lipid peroxidation vs inflammation in the development of coronary heart disease. VCAM-1: Vascular cell adhesion molecule-1; ICAM-1: Intracellular cell adhesion molecule-1; MCP-1: Monocyte chemoattractant protein-1; MCSF-1: Monocyte colony stimulating factor; LDL: Low density lipoprotein; NF-κB: Nuclear factor κB; ROS: Reactive oxygen species.

Figure 2 Mechanism for the transcriptional regulation by liver X receptor (LXR). RXR: Retinoid X receptor.

Figure 3 Classification of LXR modulators.

Figure 4 Diverse biological functions of LXRs. ACC: Acyl coenzyme A carboxylase; FAS: Fatty acid synthase; SCD1: Sterol coenzyme A desaturase 1; PLTP: Phospholipids transfer protein; iNOS: Inducible nitric oxide synthase; COX2: Cyclo-oxygenase 2; IL: Interleukin; MMP-9: Matrix mettaloproteinase-9; TNF: Tumor necrosis factor; TF: Tissue factor.

Figure 5 Decision maker: LXR vs PPARγ.