Lack of new antiinfective agents: Passing into the pre-antibiotic age?

Table 1 Nomenclature of terms used in severe systemic infections

Term	Definition
Endotoxemia	Occurrence of Lipopolysaccharide (Endotoxin) in Blood
Bacteremia	Occurrence of living bacteria in blood
SIRS	Generalized hyperinflammatory reaction with different causes, Infections, Burns, Traumata
Sepsis	SIRS induced by an infection
Severe Sepsis	Sepsis with organ dysfunction
Septic Shock	Sepsis with shock

SIRS: Systemic inflammatory response syndrome.