Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Figure 1 The roles of the myomiRs during embryonic tissue differentiation and adult tissue regeneration. Elevated levels of miR-1 and miR-133a are essential for differentiation of cardiac muscle[10,15], whilst miR-1, miR-206 and miR-133b are required for skeletal muscle differentiation[7,13]. Elevation of miR-133b levels in adipose stem cells leads to differentiation to a nerve-cell like fate[71], whilst reduction in miR-133b leads to brown fat cell differentiation[74]. Strong depletion of miR-133b and elevated Fgf allows regeneration of damaged zebrafish appendages[67,68].