Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

Figure 1 A schematic representation of human IQGAP1. The domains are shown on a linear representation of the protein sequence. The folded protein is unlikely to be arranged in a linear fashion and it is possible that some of these domains contact each other. CHD: Calponin homology domain (residues 44-159); WW: WW domain (679-712); IQ: IQ-motifs containing region (745-864); GRD: GAP-related domain (1004-1237); RGC: Ras-GAP C-terminal domain (1563-1657). The definitions of the domain boundaries are those of Briggs and Sacks[2].