Review
Copyright ©2012 Baishideng Publishing Group Co.
World J Biol Chem. Jan 26, 2012; 3(1): 7-26
Published online Jan 26, 2012. doi: 10.4331/wjbc.v3.i1.7
Figure 13
Figure 13 Regulation of TRAMP4 polyadenylation by Mtr4p. Mtr4p has a novel function as a regulator of TRAMP polyadenylation. Addition of the first four adenylates to a TRAMP substrate is accelerated by Mtr4p, whereas the subsequent adenylates (i.e., A5 to An) are added more slowly, suggesting that interrogation of the 3′-end of a substrate by Mtr4p plays a significant role in this regulation[139].