Zinc finger structure-function in Ikaros Marvin A Payne

Figure 3 Structure of an engineered peptide with three tandem zinc fingers similar to Ikaros ZF2-3. The views shown are from 1MEY (pdb), an engineered three tandem zinc finger peptide (shown in red) in complex with cognate DNA[4] shown in green. All three fingers show the zinc (grey sphere) complexed to two sulfurs of cysteine (yellow) and two imidazole nitrogen (blue). A: An overview of the zinc fingers nestled in the major groove of the DNA. The N terminus is on the left. The C-terminal finger has the DNA-interacting side chains shown; B: A view of the N-terminal finger showing the seven essential residues for zinc finger structural integrity; C: A view of the DNA-interacting residues on the C-terminal finger, -1:arg, 2:asp, 3:his, 6:arg. The views were produced using CHIMERA[35].