Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 26, 2015; 6(4): 310-323
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.310
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.310
Modulation of the matrix redox signaling by mitochondrial Ca2+
Jaime Santo-Domingo, Andreas Wiederkehr, Umberto De Marchi, Mitochondrial Function, Nestlé Institute of Health Sciences, CH-1015 Lausanne, Switzerland
Author contributions: All authors contributed to this manuscript
Conflict-of-interest statement: The authors are employees of NIHS which is part of Nestle Group.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Umberto De Marchi, PhD, Mitochondrial Function, Nestlé Institute of Health Sciences, EPFL Innovation Park, Batiment G, CH-1015 Lausanne, Switzerland. umberto.demarchi@rd.nestle.com
Telephone: +41-21-6326122
Received: July 4, 2015
Peer-review started: July 10, 2015
First decision: July 31, 2015
Revised: September 23, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: November 26, 2015
Peer-review started: July 10, 2015
First decision: July 31, 2015
Revised: September 23, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: November 26, 2015
Core Tip
Core tip: Deregulated redox signaling in mitochondria leads to mitochondrial dysfunction, associated with several disorders and disease states. Matrix Ca2+ rising can be linked through multiple pathways to the mitochondrial redox state. Here we describe recent progress in the field of mitochondrial Ca2+ handling. We further summarize how mitochondrial Ca2+ signals are influencing the mitochondrial redox state. This link between Ca2+ and redox signals is likely of central importance in the regulation of mitochondrial function in health and disease.