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World J Biol Chem. May 26, 2013; 4(2): 18-29
Published online May 26, 2013. doi: 10.4331/wjbc.v4.i2.18
Published online May 26, 2013. doi: 10.4331/wjbc.v4.i2.18
Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound
Zaifang Yu, Jarrod D Predina, Guanjun Cheng, Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, Philadelphia, PA 19104, United States
Zaifang Yu, Jarrod D Predina, Guanjun Cheng, Department of Surgery, Thoracic Surgery Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104, United States
Author contributions: Cheng G drafted manuscript; Yu Z and Predina JD revised manuscript.
Supported by NCI PO1 CA 66726
Correspondence to: Dr. Guanjun Cheng, Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, United States. guanjun@mail.med.upenn.edu
Telephone: +1-215-5732593 Fax: +1-215-5734469
Received: January 14, 2013
Revised: March 19, 2013
Accepted: April 28, 2013
Published online: May 26, 2013
Revised: March 19, 2013
Accepted: April 28, 2013
Published online: May 26, 2013
Core Tip
Core tip: We recently demonstrated that a small, cell-permeable compound, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), was able to induce production of interferon (IFN)-γ and IFN-β-dependent proteins and protect epithelial cells in vitro from virally-induced cell death and to protect mice from a lethal dose of H1N1 influenza A virus. DMXAA that activates multiple antiviral pathways including IFN-β pathway is an attractive strategy in antiviral therapies. Nucleotide oligomerization domain 1 pathway may play an important role in refractoriness of IFN-β signaling in mouse respiratory epithelial cells induced by DMXAA.