Preoperative interleukin-17a as a predictor of acute pancreatitis after pancreaticoduodenectomy

Table 5 Subgroup analyses of risk factors for post pancreatectomy acute pancreatitis-associated postoperative pancreatic fistula

Risk factors	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
CRP, mg/L	0.85 (0.72-1.34)	0.17A9
IFN-α, pg/mL	3.84(2.25-6.84)	0.164
IFN-γ, pg/mL	1.86 (0.64-5.36)	0.252
IL-2, pg/mL	2.12 (0.82-5.12)	0.148
IL-17a, pg/mL	1.24 (1.12-1.36)	< 0.001	1.12 (1.11-1.16)	< 0.001
Age, years	0.75 (0.45-1.19)	0.268
Sex, male vs female	0.64 (0.38-1.04)	0.068
BMI, kg/m2	1.06 (0.58-2.17)	0.896
Albumin < 35 g/L	2.56 (1.37-4.77)	0.002
PBD, yes vs no	1.34 (0.74-2.36)	0.384
Pancreatic texture, soft vs firm	0.96 (0.55-1.69)	0.889
MPD ≤ 3 mm	1.36 (0.84-2.26)	0.265
Venous resection, yes vs no	1.38 (0.86-2.22)	0.247
Surgical procedure, RPD vs OPD	2.08 (1.26-3.44)	0.004
Operative time > 300 minutes	1.19 (0.65-1.86)	0.782
Estimated blood loss > 200 mL	2.78 (1.51-5.12)	0.001

PBD: Pancreatic biliary drainage; BMI: Body mass index; IL-17a: Interleukin-17A; CRP: C-reactive protein; RPD: Robotic pancreaticoduodenectomy; OPD: Open pancreaticoduodenectomy; POPF: Postoperative pancreatic fistula.