Preoperative interleukin-17a as a predictor of acute pancreatitis after pancreaticoduodenectomy

Table 4 Risk factor assessment for post pancreatectomy acute pancreatitis: A two-tiered statistical evaluation

Risk factors	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
IL-17a ≥ 4.5 pg/mL	3.85 (2.14-6.91)	< 0.001	4.67 (2.49-8.72)	< 0.001
WBC > 10 × 109/L	1.86 (0.64-5.36)	0.252
NE > 7 × 109/L	2.12 (0.82-5.12)	0.148
Age, years	1.11 (0.99-1.02)	0.382
Sex, male vs female	0.70 (0.43-1.13)	0.168
BMI, kg/m2	1.06 (0.97-1.03)	0.194
ASA ≥ III	0.75 (0.45-1.19)	0.268
Total bilirubin ≥ 24 μmol/L	0.64 (0.38-1.04)	0.068
Venous resection, yes vs no	1.34 (0.74-2.36)	0.384
Surgical procedure, RPD vs OPD	0.96 (0.55-1.69)	0.889
Operative time > 300 minutes	1.36 (0.84-2.26)	0.265
Estimated blood loss > 200 mL	1.38 (0.86-2.22)	0.247
Pathology (not PDAC/CP)	2.08 (1.26-3.44)	0.004	1.89 (1.08-3.30)	0.025

PDAC: Pancreatic ductal adenocarcinoma; CP: Chronic pancreatitis; WBC: White blood cell; NE: Neutrophils; IL-17a: Interleukin-17A; BMI: Body mass index; RPD: Robotic pancreaticoduodenectomy; OPD: Open pancreaticoduodenectomy.