Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn’s disease: A systematic literature review

Figure 3 Treatment algorithms showing the first, second, third, and fourth treatments among studies showing sequential treatments (n = 15). The first treatment in a study is presented on the left of the figure with the number of corresponding treatment algorithms. The lines then flow to the next treatment mentioned in the studies; line thickness corresponds to the number of treatment lines. Of note one study may report more than one treatment per line; for example, one study by Graf et al[49] reported that patients underwent loose seton placement as a first treatment followed by fistulectomy/-otomy, advancement flap, or plug, representing three different treatments as a second treatment in this study.