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©The Author(s) 2025.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 106777
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.106777
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.106777
Figure 3 Mitochondrial alanyl-tRNA synthetase 2 epigenetically upregulates acyl-CoA synthetase long-chain family member 4 expression via histone lactylation.
A and B: The (A) protein expression [Protein levels of acyl-CoA synthetase long-chain family member 4 (ACSL4) in Caco-2 cells normalized to β-actin. Bar graphs show densitometric quantification (mean ± SD)] and (B) RNA level of ACSL4 in Caco-2 cells that depleted of AARS2; C: The enrichment of H3K18 La in histone of ACSL4 gene; D: The luciferase activity of ACSL4 gene promoter. aP < 0.01 vs shNC.
- Citation: Dong W, Huang SX, Qin ML, Pan Z. Mitochondrial alanyl-tRNA synthetase 2 mediates histone lactylation to promote ferroptosis in intestinal ischemia-reperfusion injury. World J Gastrointest Surg 2025; 17(6): 106777
- URL: https://www.wjgnet.com/1948-9366/full/v17/i6/106777.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v17.i6.106777