Quality of life and outcomes in patients undergoing endoscopic papillectomy vs surgical treatment for duodenal papillary adenomas

Table 3 Comparison of postoperative quality of life, occurrence of follow-up complications, adverse events, and long-term outcomes between endoscopic papillectomy and surgical treatment, n (%)

Variable	EP (n = 155)	Surgery (n = 43)	P value
Quality of life
PCS score, median (IQR)	54.2 (51.7-55.9)	53.0 (46.0-55.1)	0.008
≥ 50	129 (83.2)	29 (67.4)	0.023
MCS score, median (IQR)	55.9 (51.7-60.7)	48.6 (41.8-56.0)	< 0.001
≥ 50	124 (80.0)	20 (46.5)	< 0.001
Follow-up time, months, median (IQR)	37.0 (25.0-54.0)	46.0 (25.0-65.0)	0.451
Range	13-131	5-91	0.113
≤ 24	38 (24.5)	10 (23.3)
25-60	85 (54.8)	19 (44.2)
61-120	26 (16.8)	14 (32.5)
> 120	6 (3.9)	0 (0.0)
Follow-up pancreatitis	8 (5.2)	0 (0.0)	0.279
Follow-up cholangitis	6 (3.9)	2 (4.7)	1.000
Follow-up bile duct stones	12 (7.7)	1 (2.3)	0.357
Abdominal pain	32 (20.6)	14 (32.6)	0.102
Frequency of abdominal pain			0.001
Infrequent	25 (16.1)	9 (20.9)
Sometimes	7 (4.5)	5 (11.6)
Region of abdominal pain			< 0.001
Back	1 (0.6)	0 (0.0)
Epigastric region	14 (9.0)	10 (23.3)
Right upper abdomen	9 (5.8)	0 (0.0)
Right lower abdomen	1 (0.6)	0 (0.0)
Left upper abdomen	7 (4.5)	3 (7.0)
Left lower abdomen	0 (0.0)	1 (2.3)
Abdominal pain classification			< 0.001
Sting	2 (1.3)	0 (0.0)
Colic	2 (1.3)	1 (2.3)
Hidden anguish	22 (14.2)	10 (23.3)
Distending pain	6 (3.9)	3 (7.0)
Appetite decline	10 (6.5)	7 (16.3)	0.084
Weight loss	15 (9.7)	9 (20.9)	0.047
Poor sleep	26 (16.8)	9 (20.9)	0.527
Bleeding
Postoperative bleeding	9 (5.8)	1 (2.3)	0.597
Delayed bleeding	11 (7.1)	0 (0.0)	< 0.001
Pancreatitis	17 (11.0)	1 (2.3)	0.149
Cholangitis	2 (1.3)	0 (0.0)	1.000
Perforation	4 (2.6)	0 (0.0)	0.579
Papillary stricture	2 (1.3)	0 (0.0)	1.000
Pancreatic fistula	0 (0.0)	10 (23.3)	< 0.001
Biliary fistula	0 (0.0)	2 (4.7)	0.046
Chylous fistula	0 (0.0)	1 (2.3)
Abdominal infection	0 (0.0)	15 (34.9)	< 0.001
Infection of incisional wound	0 (0.0)	2 (4.7)	0.046
Regular review	133 (85.8)	41 (95.3)	0.090
Recurrence	8 (5.2)	1 (2.3)	0.176
Post-relapse treatment
Untreated	2 (25.0)	0 (0.0)
EMR	4 (50.0)	1 (100.0)
EMR with submucosal injection	2 (25.0)	0 (0.0)

EP: Endoscopic papillectomy; IQR: Interquartile range; PCS: Physical component summary; MCS: Mental component summary; EMR: Endoscopic mucosal resection.