Clinical significance of immune cell and biomarker changes in liver cancer

Table 4 Diagnostic value of peripheral natural killer cell subsets as well as alpha fetoprotein and glutamyl transpeptidase in primary liver cancer

Indicators	Cut-off	AUC	Sensitivity (%)	Specificity (%)	Youden index	95%CI	P value
CD8+CD56+NKT	> 7.30%	0.686	70.00	66.67	0.367	0.550-0.822	0.007
CD3+CD161+NKT	> 13.80%	0.786	83.33	80.00	0.633	0.659-0.912	< 0.001
CD3-CD161+NKT	> 11.01%	0.758	80.00	76.67	0.567	0.627-0.888	< 0.001
AFP	> 309.65 ng/mL	0.628	56.67	76.67	0.333	0.482-0.774	0.086
GGT	> 114.79 U/mL	0.568	53.33	66.67	0.200	0.420-0.716	0.370
Combined	-	0.898	86.67	80.00	0.667	0.817-0.979	< 0.001

AFP: Alpha fetoprotein; AUC: Area under the curve; CD: Cluster of differentiation; GGT: Gamma-glutamyl transpeptidase; NKT: Natural killer T cell; PLC: Primary liver cancer.