Proximal gastrectomy with tubular stomach reconstruction vs total gastrectomy for proximal gastric cancer following neoadjuvant chemotherapy: A multicenter retrospective study

Table 5 Univariate Cox regression analysis for overall survival

Variables	Hazard ratio (95%CI)	P value
Group
PG	1.00 (Reference)
TG	1.15 (0.87-1.54)	0.330
Histological differentiation
Moderate/Well	1.00 (Reference)
Poor/others	3.60 (2.52-5.14)	< 0.001
Tumor size
> 4 cm	1.00 (Reference)
≤ 4 cm	0.18 (0.12-0.27)	< 0.001
Gender
Female	1.00 (Reference)
Male	0.88 (0.62-1.26)
Age
> 70	1.00 (Reference)
≤ 70	0.77 (0.53-1.13)
BMI
> 24 kg/m2	1.00 (Reference)
≤ 24 kg/m2	1.10 (0.83-1.47)
Clavien-Dindo Classification
> Grade II	1.00 (Reference)
≤ Grade II	0.68 (0.42-1.11)
TRG
> 1	1.00 (Reference)
≤ 1	0.95 (0.68-1.32)
NACT plus immunotherapy
No	1.00 (Reference)
Yes	0.71 (0.53-0.94)
NACT regimens
Others	1.00 (Reference)
SOX	0.97 (0.73-1.29)
NACT cycles
> 4	1.00 (Reference)
≤ 4	0.83 (0.56-1.25)
Vascular invasion
No	1.00 (Reference)
Yes	1.19 (0.87-1.63)
Perineural invasion
No	1.00 (Reference)
Yes	1.34 (1.00-1.81)
CR response
CR	1.00 (Reference)
Non-CR	1.25 (0.72-2.16)
Radical resection
R0	1.00 (Reference)
R1	0.81 (0.20-3.29)
ypT Stage
> T2	1.00 (Reference)
≤ T2	0.58 (0.43-0.79)
ypN Stage
> N0	1.00 (Reference)
N0	0.68 (0.48-0.96)

NACT: Neoadjuvant chemotherapy treatment; PG: Proximal gastrectomy; TG: Total gastrectomy; TRG: Tumor regression grade; CR: Complete response.