Liver transplantation for combined hepatocellular cholangiocarcinoma: Current evidence, selection criteria, and therapeutic controversies

Table 2 Liver transplantation criteria for combined hepatocellular cholangiocarcinoma

Criteria	Tumor size	Nodules	Vascular invasion	Risk stratification
Milan	≤ 5 cm	≤ 3	Excluded	None
UCSF	≤ 6.5 cm	≤ 3 (total tumor burden ≤ 8 cm)	Excluded	None
SEER-derived RSM[55]	> 2 cm (+ 1 point)	≥ 3 (+ 2 points)	+ 1 point	Low-risk: ≤ 2 points; high-risk: > 2 points or extrahepatic metastasis
“Very early” stage cHCC-CCA[38]	≤ 2 cm	1-2	Excluded	None

UCSF: University of California, San Francisco; SEER: Surveillance, Epidemiology, and End Results; RSM: Risk scoring model; cHCC-CCA: Combined hepatocellular cholangiocarcinoma.