Research progress on O-GlcNAcylation in the occurrence, development, and treatment of colorectal cancer

Table 4 Therapeutic targets associated with O-GlcNAcylation and colorectal cancer

Target/Drug	Binding site/Pathway	Result
Ac-5SGlcNAc[58]	HBP	Form UDP-5SGlcNAc, and greatly decrease O-GlcNAc levels in CRC
BGJ398[59]	FGF/FGFR2 signaling pathway	Block the effect of C1GALT1 on the malignant behavior of CRC cells. C1GALT1 could be a target for treating CRC
MYBL1[60]	-	Be involved in the suppression of gene expression in CRC
sTn antigen[61]	Core 1-mediated O-glycans biosynthesis pathway	Synthesize more truncated CD44 proteins
Tn antigen[47,63]	T-synthase/COSMC pathway	Play an essential part of the design of therapeutic carbohydrate conjugate antitumor vaccine
mAbs B72.3 and CC49[113]	TAG-72	To help develop anti-Tn targeting vaccines
VVA and PNA lectins[68]	FGFR2	Targeting C1GALT1 is a promising strategy to reduce the number of CRC tumor stem cells
SIRT1[71]	GAPDH-C150	The binding of SNO-GAPDH to SIRT1 was selectively prevented in vitro
GalNAc-T6[23]	HLA class II histocompatibility antigen chain	Block the interaction between CD74 and MHC class II molecules
NHEJ inhibitors[73]	(1) HBP; (2) NHEJ	Regulate DNA repair
mAbs[74]	(1) ADCC; (2) Complement activation	Enhance the function of effector and remove certain glycan.
DC-SIGN[75]	MUC1 and CEA proteins	Improves tumor-specific T cell response and long-term tumor regression
β- catenin inhibitor KYA1797K[81]	β-catenin/STT3 signaling pathway	Reduce the stability of PD-L1, inhibit immune evasion, induce the apoptosis of Cancer stem cells, and promote the development of immunotherapy for CRC
Sunitinib[88]	NOTCH 1 signaling pathway/NOTCH 1 signaling pathway	Inhibit the expression of SW480. However, the specific regulatory mechanism needs to be further studied
Baicalin and Curcumin[88]	NOTCH 1 signaling pathway	Inhibit the proliferation and promote the apoptosis of CRC SW480 cells
CHK1/2 inhibitors	DNA damage response pathway	Undermine OGT stability and suppress replication, mitosis and cytokinesis of CRC cell
DR-5 and DR-4[97]	(1) DR-mediated signaling pathway; (2) Tenovin-6	Enhance the cytotoxic effect of oxaliplatin in CRC by up-regulating

COSMC: Core 1 β3-galactosyltransferase; CRC: Colorectal cancer; FGF: Fibroblast growth factor: FGFR2: Fibroblast growth factor receptor 2; HBP: Hexosamine biosynthetic pathway; MHC: Major histocompatibility complex; MYBL1: MYB proto-oncogene like 1; OGT: O-linked N-acetylglucosamine transferase; PNA: Peanut agglutinin; STn: Sialic acid Tn; VVA: Vicia villosa.