Exosomal noncoding RNAs in cholangiocarcinoma: Laboratory noise or hope?

doi:10.4240/wjgs.v12.i10.407

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Oct 27, 2020 (publication date) through Apr 15, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Oct 27, 2020; 12(10): 407-424
Published online Oct 27, 2020. doi: 10.4240/wjgs.v12.i10.407

Table 2 Potential clinical application of selected extracellular vesicle-derived long noncoding RNAs as biomarkers in cholangiocarcinoma

lncRNA	Expression	Type of EVs	EV source	Major finding	Potential application	Ref.
ENST00000517758.1 and ENST00000588480.1	↑	Exosomes	Bile samples of CCA (n = 35) and biliary obstruction patients (n = 56)	(a) ENST00000588480.1 expression may contribute to tumorigenesis and CCA progression (via p53 signaling pathway); and (b) Combined ENST00000588480.1 and ENST00000517758.1 exhibited higher sensitivity than CA19-9 (82.9% vs 74.3%)	Diagnostic value; Prognostic value/Therapeutic target	[63]
MALAT-1	↑	EVs	Serum	Upregulated in EVs from CCA vs PSC patients	Diagnostic value	[53]

lncRNA: Long noncoding RNA; EV: Extracellular vesicle; CCA: Cholangiocarcinoma; PSC: Primary sclerosing cholangitis.

Citation: Laschos K, Lampropoulou DI, Aravantinos G, Piperis M, Filippou D, Theodoropoulos G, Gazouli M. Exosomal noncoding RNAs in cholangiocarcinoma: Laboratory noise or hope? World J Gastrointest Surg 2020; 12(10): 407-424
URL: https://www.wjgnet.com/1948-9366/full/v12/i10/407.htm
DOI: https://dx.doi.org/10.4240/wjgs.v12.i10.407