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World J Gastrointest Surg. Dec 27, 2013; 5(12): 321-328
Published online Dec 27, 2013. doi: 10.4240/wjgs.v5.i12.321
Published online Dec 27, 2013. doi: 10.4240/wjgs.v5.i12.321
Timing of chemotherapy and survival in patients with resectable gastric adenocarcinoma
Amanda K Arrington, Michelle Ko, Joseph Kim, Division of Surgical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, United States
Rebecca Nelson, Department of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, United States
Supriya S Patel, Department of Surgery, University of Southern California, Los Angeles, CA 90033, United States
Carrie Luu, Department of Surgery, Harbor-UCLA Medical Center, Los Angeles, CA 90509, United States
Julio Garcia-Aguilar, Division of Colorectal Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States
Author contributions: Arrington AK, Nelson R and Kim J designed the research; Arrington AK, Nelson R and Kim J performed the research; Nelson R contributed new analytic tools; Arrington AK, Nelson R, Kim J analyzed data; Arrington AK, Nelson R, Patel SS, Luu C, Ko M, Garcia-Aguilar J and Kim J wrote the paper.
Correspondence to: Joseph Kim, MD, Associate Professor of Surgery, Division of Surgical Oncology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, United States. jokim@coh.org
Telephone: +1- 626-471-7100 Fax: +1- 626-3018865
Received: July 22, 2013
Revised: November 19, 2013
Accepted: December 12, 2013
Published online: December 27, 2013
Revised: November 19, 2013
Accepted: December 12, 2013
Published online: December 27, 2013
Core Tip
Core tip: Curative intent surgical resection offers the best survival potential in conjunction with chemotherapy for patients with gastric cancer. Few studies have evaluated the optimal timing of chemotherapy. This study shows that in the setting of resectable gastric cancer, there is no survival advantage based on the timing of chemotherapy.