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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2023; 15(3): 346-361
Published online Mar 27, 2023. doi: 10.4240/wjgs.v15.i3.346
Published online Mar 27, 2023. doi: 10.4240/wjgs.v15.i3.346
Differential expression and significance of 5-hydroxymethylcytosine modification in hepatitis B virus carriers and patients with liver cirrhosis and liver cancer
Yue-Cui Li, Wei-Yue Hu, Cheng-Hang Li, Li-Li Zhang, Xiang-Wei Xu, Jin Li, Hong-Xia Luo, Department of Infectious Diseases, The First People’s Hospital of Yongkang, Jinhua 321300, Zhejiang Province, China
Author contributions: Li YC and Hu WY conceived the experimental ideas; Hu WY and Li CH performed the data collection; Zhang LL, Xu XW, Li J and Luo HX completed data sorting and analysis; Li YC wrote this manuscript.
Supported by Science and Technology Planning Project of Zhejiang Province , No. LGF20H160001 .
Institutional review board statement: The study was reviewed and approved by The First People’s Hospital of Yongkang Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue-Cui Li, MBChB, Chief Physician, Department of Infectious Diseases, The First People’s Hospital of Yongkang, No. 599 Jinshan West Road, Yongkang, Jinhua 321300, Zhejiang Province, China. liyuecui02@yeah.net
Received: December 12, 2022
Peer-review started: December 12, 2022
First decision: January 5, 2023
Revised: January 17, 2023
Accepted: February 16, 2023
Article in press: February 16, 2023
Published online: March 27, 2023
Peer-review started: December 12, 2022
First decision: January 5, 2023
Revised: January 17, 2023
Accepted: February 16, 2023
Article in press: February 16, 2023
Published online: March 27, 2023
Core Tip
Core Tip: Major signaling pathways involved in differentially expressed genes are biliary secretion and insulin secretion. Abnormal secretion of bile and insulin in tumor cells may promote or symbolize the occurrence and development of liver cancer. SLC2A2 and PCK1 are the central nodes of the differential genes, which may be most closely related to the occurrence of liver cancer. FABP1, APOC3, SI, KRT20, SLC5A1, SLC10A2, RBP2, and AKR1B10 may be key genes in the protein regulatory network, and these genes may play regulatory roles after modification by 5-hydroxymethylcytosine (5hmC). Therefore, we suggest that the difference in 5hmC modification levels is related to the occurrence and progression of liver cancer.