Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells

Figure 3 Comparison of the antilipolytic effects of B6V10 and insulin in mouse and human adipocytes. Lipolysis was activated by 10 nmol/L isoprenaline and considered as a control set at 100% (iso alone, dotted line) while basal was set at 0% in: Mouse adipocytes (A) or human adipocytes (B). The observed lipolytic response to the β-adrenergic agonist was significantly reduced in the presence of insulin (100 nmol/L, closed triangle), benzylamine (1 mmol/L alone for humans, or combined with 0.1 mmol/L vanadate for mouse adipocytes, closed circle), or increasing doses of B6V10 (1-100 μmol/L, red diamonds), at: ^aP < 0.05, ^cP < 0.02, ^fP < 0.01. Mean ± SEM of 8 murine preparations (A) or 6-7 individual cases (B).