Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells

Figure 2 Influence of B6V10 on basal and isoprenaline-stimulated lipolysis in mouse adipocytes. Glycerol release was determined after 90-min incubation of mouse fat cells without (basal, closed square) or with the indicated concentrations of isoprenaline (open diamonds) or B6V10 (red symbols). A: Lack of lipolytic effect of increasing doses of B6V10 (red circles); B: Comparison of the inhibition of isoprenaline-stimulated lipolysis by 1 μmol/L B6V10 (red diamonds), 0.1 mmol/L benzylamine (open circle), 0.1 mmol/L vanadate (closed circle), or their combination (closed triangle). Mean ± SEM of 8 determinations. Significantly different from corresponding control at: ^aP < 0.05, ^dP < 0.01, ^fP < 0.001.