Neutral protamine hagedorn/regular insulin in the treatment of inpatient hyperglycemia: Comparison of 3 basal-bolus regimens

Table 3 Glycemic control among subgroups

	NPH × 1, n = 30, (%)	NPH × 2, n = 40, (%)	NPH × 3, n = 35, (%)	P
DM ≤ 10 yr
Overall	62.1 ± 24.8	47.3 ± 25.6	50.4 ± 23.4	0.17
Fasting glucose	53.7 ± 31.9	35.2 ± 30.5	42.1 ± 32.0	0.03
Random glucose	65.9 ± 24.9	51.1 ± 27.2	55.8 ± 28.2	0.25
Pre-hospital insulin
Overall	77.5 ± 12.4	37.6 ± 23.9	37.7 ± 26.1	0.012
Fasting glucose	39.5 ± 35.5	29.7 ± 27.5	24.1 ± 25.1	0.59
Random glucose	91.8 ± 7.5	41.0 ± 26.1	46.0 ± 31.2	0.01
Baseline glucose > 300 mg/dL
Overall	52.9 ± 24.5	37.7 ± 26.9	40.8 ± 20.0	0.36
Fasting glucose	38.1 ± 35.6	33.6 ± 34.8	36.0 ± 26.7	0.94
Random glucose	57.4 ± 22.4	38.7 ± 26.1	42.7 ± 22.5	0.21
HbA1c > 9% (75 mmol/mol)
Overall	55.2 ± 24.0	33.7 ± 22.6	45.8 ± 28.1	0.06
Fasting glucose	43.0 ± 33.9	25.5 ± 27.3	40.4 ± 31.0	0.18
Random glucose	60.0 ± 22.3	36.6 ± 23.1	48.2 ± 28.3	0.04
Absence of infectious disease
Overall	61.0 ± 24.1	39.8 ± 25.1	50.9 ± 25.6	0.01
Fasting glucose	50.8 ± 34.0	34.2 ± 32.8	44.1 ± 35.8	0.22
Random glucose	65.4 ± 25.4	41.8 ± 25.3	54.3 ± 26.5	0.01
Glomerular filtration rate < 60 mL/min
Overall	62.8 ± 25.3	42.0 ± 29.7	45.2 ± 16.7	0.20
Fasting glucose	40.0 ± 34.7	35.1 ± 32.8	31.2 ± 20.3	0.87
Random glucose	71.9 ± 27.3	44.4 ± 30.4	55.4 ± 29.5	0.14
Body mass index, dex ± 29.52
Overall	63.4 ± 22.8	44.1 ± 25.2	48.0 ± 23.3	0.03
Fasting glucose	47.1 ± 35.0	39.9 ± 34.0	42.1 ± 30.4	0.78
Random glucose	69.9 ± 23.1	45.6 ± 25.1	50.8 ± 23.9	0.01

Proportion of patients that achieved glycemic targets during the whole follow up. Data are expressed as X ± SD. DM: Diabetes mellitus; HbA1c: Glycosylated hemoglobin.