Hyperglycemia-induced overexpression of CREB3 L3 promotes the epithelial-to-mesenchymal transition in bladder urothelial cells in diabetes mellitus

Figure 4 Establishment of diabetic cystopathy models of rats for 4 weeks. A and B: This study established a diabetic cystopathy model in rats by feeding a high-fat and high-sugar diet and intraperitoneally injecting 1% streptozotocin; C-F: At the end of the 4-week period, the body weight, blood glucose, bladder weight and diameter of the rats were measured, and each group contained five replicates; G: The bladder tissue was retained for hematoxylin and eosin staining, and each group contained three replicates. ^aP < 0.01 vs negative control (NC) group, ^bP < 0.05 vs diabetes mellitus (DM) group.