Impact of longer diabetes duration and lower estimated glomerular filtration rate on cardiovascular complications and mortality: A nationwide population-based study

Table 2 Impact of estimated glomerular filtration rate on myocardial infarction based on diabetes duration

Diabetes duration	eGFR, mL/min/1.73 m2	n	Events (n)	Incidence rate (per 1000 person-years)	HR (95%CI)
					Model 11	Model 22	Model 33
New-onset	≥ 90	427078	4191	2.56	1 (Ref.)	1 (Ref.)	1 (Ref.)
	60–90	259089	3530	3.54	1.384 (1.323-1.447)	1.076 (1.028-1.126)	1.067 (1.020-1.117)
	30–60	18770	525	7.46	2.916 (2.663-3.193)	1.520 (1.385-1.668)	1.466 (1.336-1.609)
	< 30	767	19	6.96	2.726 (1.737-4.278)	1.523 (0.970-2.391)4	1.474 (0.939-2.314)4
	ESKD	757	18	6.44	2.519 (1.585-4.002)	1.916 (1.205-3.044)	1.909 (1.201-3.034)
< 5 yr	≥ 90	291515	3744	3.28	1.279 (1.224-1.336)	1.103 (1.055-1.154)	1.077 (1.029-1.126)
	60–90	193292	3264	4.31	1.679 (1.604-1.758)	1.150 (1.096-1.206)	1.125 (1.072-1.180)
	30–60	21810	661	7.95	3.104 (2.86-3.369)	1.590 (1.461-1.730)	1.522 (1.398-1.656)
	< 30	904	40	12.47	4.888 (3.58-6.674)	2.657 (1.945-3.629)	2.431 (1.779-3.322)
	ESKD	1079	48	12.25	4.805 (3.615-6.386)	3.655 (2.749-4.860)	3.262 (2.452-4.338)
5–9 yr	≥ 90	219064	3290	3.84	1.498 (1.432-1.568)	1.176 (1.122-1.232)	1.098 (1.047-1.151)
	60–90	173265	3538	5.23	2.039 (1.949-2.132)	1.285 (1.226-1.347)	1.207 (1.150-1.266)
	30–60	27807	941	8.89	3.469 (3.232-3.724)	1.716 (1.594-1.848)	1.584 (1.470-1.706)
	< 30	1442	77	15.11	5.926 (4.73-7.424)	3.140 (2.504-3.937)	2.756 (2.197-3.457)
	ESKD	1454	59	11.13	4.359 (3.371-5.636)	3.282 (2.537-4.245)	2.764 (2.135-3.577)
≥ 10 yr	≥ 90	201984	3803	4.87	1.904 (1.822-1.989)	1.356 (1.296-1.419)	1.158 (1.104-1.215)
	60–90	200657	5104	6.62	2.585 (2.482-2.693)	1.505 (1.440-1.573)	1.283 (1.224-1.344)
	30–60	55283	2410	11.75	4.597 (4.373-4.834)	2.240 (2.122-2.366)	1.835 (1.733-1.943)
	< 30	5010	422	24.65	9.695 (8.772-10.716)	5.039 (4.550-5.582)	3.858 (3.476-4.281)
	ESKD	4201	319	22.18	8.731 (7.792-9.784)	5.721 (5.099-6.419)	4.202 (3.737-4.725)

¹Unadjusted for age and sex.

²Adjusted for age, sex, smoking, alcohol consumption, regular exercise, low-income status, body mass index, and history of hypertension or dyslipidemia.

³Adjusted for age, sex, smoking, alcohol consumption, regular exercise, low-income status, body mass index, history of hypertension or dyslipidemia, use of insulin, and ≥ 3 oral glucose-lowering drugs.

⁴Insignificant values.

eGFR: Estimated glomerular filtration rate; ESKD: End-stage kidney disease; HR: Hazard ratio; CI: Confidence interval.