Analysis of N6-methyladenosine-modified mRNAs in diabetic cataract

Figure 7 Validation of the diverse expression levels of methylated mRNA and RNA methyltransferase, using in vivo and in vitro models. A: Methylation levels of BECN2, METTL21A, NFE2, and TIPRL are consistent with the microarray data for the diabetic cataract and normal control groups; B: Intersection results of upregulated mRNAs and N6-methyladenosine-related genes; C: Fold change values of five genes (RBM15, WTAP, ALKBH5, FTO, and YTHDF1) in microarray results; D: The mRNA levels of RBM15 are significantly higher in high-glucose cultured SRA01/04 cells than in normal-glucose cultured ones. DC: Diabetic cataract; NC: Normal control; HG: High-glucose; NG: Normal-glucose. ^aP < 0.05.