miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2

Figure 3 miR-124 targeted EZH2 and downregulated the expression of EZH2. A: miR-124 targeted EZH2 verified by a double luciferase reporter gene assay. B: The relative expression levels of EZH2 mRNA were upregulated by miR-124 inhibitor in high glucose-induced Min6 cells detected by real-time quantitative polymerase chain reaction; C: The relative expression of EZH2 protein was upregulated by miR-124 inhibitor in HG-induced Min6 cells detected by western blot. ^aP < 0.05, vs the mimic-NC group; ^bP < 0.05, vs BC group; ^cP < 0.05, vs the HG group. NC: Normal control; BC: Blank control; HG: High glucose.