Characterization of gut microbial and metabolite alterations in faeces of Goto Kakizaki rats using metagenomic and untargeted metabolomic approach

Table 2 Metabolism pathway enrichment analysis

Pathway name	Match status	P value	-log (p)	Impact	Pathway level
Arginine biosynthesis	2/14	0.0055854	2.2529	0.19797	Amino acid metabolism
Primary bile acid biosynthesis	3/46	0.0056824	2.2455	0.05721	Lipid metabolism
Purine metabolism	3/65	0.014896	1.8269	0.0	Nucleotide metabolism
Alanine, aspartate and glutamate metabolism	2/28	0.021712	1.6633	0.09776	Amino acid metabolism
Linoleic acid metabolism	1/5	0.04129	1.3842	1.0	Lipid metabolism
Nitrogen metabolism	1/6	0.049357	1.3066	1.0	Energy metabolism
Vitamin B6 metabolism	1/9	0.073183	1.1356	0.0	Metabolism of cofactors and vitamins
Glutathione metabolism	1/28	0.21173	0.67421	0.25596	Metabolism of other amino acids
Glyoxylate and dicarboxylate metabolism	1/32	0.23835	0.62279	0.0	Carbohydrate metabolism
Glycine, serine and threonine metabolism	1/33	0.24487	0.61107	0.00245	Amino acid metabolism
Biosynthesis of unsaturated fatty acids	1/36	0.26413	0.57818	0.0	Lipid metabolism