Review
Copyright ©The Author(s) 2023.
World J Diabetes. Jan 15, 2023; 14(1): 1-16
Published online Jan 15, 2023. doi: 10.4239/wjd.v14.i1.1
Table 2 Results of various trials that used traditional Chinese medicines topically
Ref.
Test group
Control group
Results
Li et al[28]Hongyou ointment and Shengji powder (CM group) (n = 27)WM (mupirocin ointment, growth factor, and vaseline gauze) (n = 26)Overall effective rate (healed and completely effective) in CM group (22/27, 81.48%) was significantly higher than that in WM group (15/26, 57.69%, P = 0.04). The mean wound healing time was 22.71 ± 5.46 d in CM group vs 26.56 ± 7.56 d in WM group (t = 2.13, P = 0.04)
Liu et al[32]CPCFKFSCPCF group: Initial wound area was 7.58 ± 2.13 cm2, improved to 3.83 ± 3.13 cm2 on 14th d, 2.39 ± 2.53 cm2 on 21st d, and 1.18 ± 2.49 cm2 on 28th d. The mean wound area of 7.73 ± 2.11 cm2 in KFS group had improved through 5.66 ± 2.58 cm2 on day 14, 4.42 ± 2.87 cm2 on day 21, and 2.78 ± 3.32 cm2 on 28th d (P < 0.05)
Huang et al[39]ON101 cream (n = 118)Sodium carboxymethyl cellulose absorbant dressing (n = 112)At 16 wk, 74 patients (60.7%) of ON101 group and 40 (35.1%) of comparison group had achieved ulcer closure (OR = 2.84; 95%CI 1.66-4.84; P < 0.001). No difference between rates of 50% ulcer reduction at 16 wk (82.8% vs 86.0%)
Li et al[35]TYO (n = 24)SWT (n = 24)Improved healing rate of only 4% (37.5% TYO group vs 33.3% SWT group). Significant improvement in TYO group at 12 wk (79.2% vs 41.7%; P = 0.017) and 24 wk (91.7% vs 50%; P = 0.003)
Xie et al[37]SH (n = 30)Recombinant human basic FGF gel ( n = 30)Significant reduction in ulcer size by 4, 8, and 12 wk. Ulcer size was reduced from 15.90 ± 3.27 cm2 to 2.75 ± 1.08 cm2 in the SH group and from 15.72 ± 3.11 cm2 to 8.36 ± 2.07 cm2 in controls (P < 0.001)
Jiang et al[40]Jingwanhong ointment (n = 67)Sulphadiazine zinc ointment (n = 64)Epithelization was complete by 46.5 ± 15.6 d in Jingwanhong group and 67.9 ± 17.9 d in sulfadiazine zinc group (P < 0.05)
Cao et al[41]Unspecified TCM ointment (n = 20)Topical ethacridine lactate (n = 20)Better wound healing at 10, 20, and 30 d in TCM group
FGF: Fibroblast growth factor; CM: Chinese medicine; WM: Western medicine; CPCF: Cortex Phellodendri Compound Fluid; KFS: Kangfuxin solution; TCM: Traditional Chinese medicines; TYO: Tangzu Yuyang Ointment plus standard therapy; SWT: Standard wound therapy; SH: Shenghong liquid.